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Here’s a new article I just found:
Byetta: A multi-pronged approach to glucose control
In April 2005 the FDA approved Byetta, an injectable medication, as an adjunct
treatment for adults with Type 2 diabetes who cannot achieve good glucose
control with oral medications such as metformin, a sulfonylurea or a combination
of these medicines. Some people will find the improved glucose control and
weight loss worth the twice-daily injections.
What it does: Byetta works on several organ systems affected by diabetes: It
increases insulin secretion from the pancreas, decreases glucose release from
the liver, lessens glucose absorption by slowing digestion and curbs appetite.
The medication has been found to reduce A1C levels moderately, about one
percent. And though Byetta may produce some weight loss, it is not prescribed
for that indication.
Who can take it: Byetta is approved for adults with Type 2 diabetes who do not
take insulin or use oral diabetes medications: thiazolidinediones,
non-sulfonylurea insulin secretagogues or alpha-glucosidase inhibitors. It
should not be used by anyone with gastroparesis (nerve damage that slows
emptying of the stomach’s contents into the small intestine), kidney disease or
during pregnancy. "It’s important to be screened for gastroparesis before
starting this medication," stresses Rodriguez. Symptoms of gastroparesis are
early feelings of fullness, unexplained nausea, spontaneous vomiting and
constipation. If you are experiencing any of these symptoms, discuss them with
your doctor.
Side effects: Side effects may include nausea, vomiting, diarrhea and headaches.
"About 40 percent of people who take Byetta experience nausea, but I have found
it to be less when patients are started on the lowest dosage and then gradually
increased," says Rodriguez. Even though Byetta alone does not cause
hypoglycemia, it is commonly used with a sulfonylurea and this medication might
cause low blood glucose.
Taking Byetta properly: Byetta comes in pre-filled pens and is injected twice a
day, one hour or less before morning and evening meals. Unlike insulin, which
must be adjusted to lower glucose levels and food intake, you take the same dose
of Byetta each time, so there’s no guessing on the correct dosage. Because this
medication slows digestion, tell your doctor about all other medications you