Oral Meds & Byetta

DRUG INTERACTIONS: Exenatide slows down transit of food and drugs through
the intestine and, therefore, can reduce the absorption of drugs that are
taken orally. To avoid this interaction, administer oral medications one
hour before exenatide is administered. Orally administered drugs that need
to be administered with food should be given with a light meal or snack when
exenatide is not administered.

Does this mean that I should take my metformin and glyburide BEFORE my
Byetta? I usually take the Byetta about 30 minutes before the meal and my
oral meds at the start of the meal.

8 Responses to “Oral Meds & Byetta”

  1. Saul Ma Says:

    I take my oral’s anywhere between an hour and two hours after I have eaten. I
    usually inject, eat within the hour and then an hour (or two if I forget) I take
    the orals. It works for me.

    melodie

    Does this mean that I should take my metformin and glyburide BEFORE my
    Byetta? I usually take the Byetta about 30 minutes before the meal and my
    oral meds at the start of the meal.

  2. Devin Annamae Says:

    I do as Melodie does and it works well for me too.

  3. Goldie Rana Says:

    I spoke with my diabetes educator this afternoon and she said that
    while glyburide can be taken before or after a meal, that
    metformin should be taken before the meal and preferably at the
    start of the meal to minimize intestinal distress. Since I’ve
    been on metformin for almost nine months now, she recommends that
    I take both oral meds 1 hour prior to my Byetta injection.

    –Michael

  4. Goldie Rana Says:

    I spoke with my diabetes educator this afternoon and she said that
    while glyburide can be taken before or after a meal, that
    metformin should be taken before the meal and preferably at the
    start of the meal to minimize intestinal distress. Since I’ve
    been on metformin for almost nine months now, she recommends that
    I take both oral meds 1 hour prior to my Byetta injection.

    –Michael

  5. Traci Mcgee Says:

    I spoke with my diabetes educator this afternoon and she said that
    while glyburide can be taken before or after a meal, that
    metformin should be taken before the meal and preferably at the
    start of the meal to minimize intestinal distress. Since I’ve
    been on metformin for almost nine months now, she recommends that
    I take both oral meds 1 hour prior to my Byetta injection.

    –Michael

    [Non-text portions of this message have been removed]

  6. Traci Mcgee Says:

    I do as Melodie does and it works well for me too.


    Always with a smile,

  7. Neva Marjory Says:

    I do the Byetta before breakfast. Take my AM med’s at 11am with
    lunch…then Byetta before dinner…and pm meds about 8pm with milk or
    cheese/crackers.

    It was difficult figuring out how to get all the meds in during the
    day!!! Sheesh.

    I have been on Byetta three weeks. No nausea. I have totally lost my
    appetite. Nothing sounds good and I forget to eat. My husband reminds
    me to eat. I’ve noticed I don’t finish my plate at resturants either.

    BS readings are good. Down from 250’s to 140 -180’s…and dropping.

    I am a Byetta fan for sure.

  8. Sheryl Ileana Says:

    This is a tough one, and it seems everyone has a different answer. Personally,
    I took everything together first thing in the morning and ate about 10 carbs and
    was good for the day with meds, and satisfied with a small lunch. Then started
    worrying about spacing and time and food, so I talked to the endo, who helped me
    develop a very elaborate schedule for meds and food and exercise, etc. Of
    course, I became non-compliant within about 3 days, and by the end of the week
    was eating all day and only remember to take about 1/2 the meds. Now, when I
    wake up I take the shot and the meds and eat on the way to the shower - I’m back
    to controlled appetite, controlled bs, and the weight is coming off again.
    Please let me stress, though, that my meds are: Metformin ER, Cozaar, Zorcor,
    Premarin, Aspirin, Prenatal Vitamins, CoQ10, and echinacea. None of these are
    antibiotics, steroids, or birth control pills (there are 2-3 more types of meds
    you’re not supposed to take with the
    shot, too).
    I believe that just like shot location, you just have to see what is going to

    work best for you, and be the most effective.

    Oh, yeah - one more thing - Test, Test, Test.

    Best wishes
    -April

Leave a Reply

You must be logged in to post a comment.