SOMOGYI EFFECT
Sunday, June 11th, 2006*SOMOGYI EFFECT*
Somogyi Effect, named for Dr. Robert Somogyi, its discoverer, is a high
morning BG due to a low overnight. It is most commonly seen with insulin
using diabetics, but is also seen with overnight reactive hypoglycemics.
The mechanism is a low overnight, which causes the body to react by
releasing many of the same hormones seen in DP. The strongest blood glucose
increasing hormone, *glucagon*, plays an important role. It tells your liver
to start glycogenolysis and gluconeogenesis to provide enough glucose for
your body to survive. This is sometimes referred to as a *Liver Dump. *Often,
this mechanism over-produces, and you wake to a significantly higher BG.
Setting your bedtime BG target a bit higher, will usually prevent you from
having a hypoglycemic event overnight.