a few more questions
yesterday i was absolutely starved all day! now i didn’t eat more than i
have been but i wanted to.
it surprised me cause i have been living on lettuce salads, eggs, a few
strawberries, some small amounts of meats, and a bit of cheeses. here’s
what’s strange though…i may or may not have hit a vein when i took my
morning dose of spit.
i hate the pen since you can’t pull back the plunger to check for blood.
however, i assumed that since the pen needles are so short that i wouldn’t
hit a vein. but i wonder if the sudden hunger was like not having the spit
for the full 6 hours.
is there anyway to make sure you don’t hit wrong with the pen?
and now for a potty question…is it normal to only have a bowel movement
every 3 days? seems like i just got over the trots then 3 days till i went
again.
jodi
June 16th, 2004 at 4:00 pm
How were your bg levels? Could your pen have gotten too cold? Pat in ID
yesterday i was absolutely starved all day! now i didn’t eat more than i
have been but i wanted to.
it surprised me cause i have been living on lettuce salads, eggs, a few
strawberries, some small amounts of meats, and a bit of cheeses. here’s
what’s strange though…i may or may not have hit a vein when i took my
morning dose of spit.
i hate the pen since you can’t pull back the plunger to check for blood.
however, i assumed that since the pen needles are so short that i wouldn’t
hit a vein. but i wonder if the sudden hunger was like not having the spit
for the full 6 hours.
June 17th, 2004 at 3:17 am
andrew you are correct. first the kidney filters it,
and then the Complete breakdown of polypeptides to
their amino acids
June 17th, 2004 at 4:11 pm
so i would think that they kidney breaks it down and
any protien remaning would go thru the above process
Large multi-protein complexes that are resident in the
cytoplasm have been shown to degrade misfolded
proteins. These complexes known as ‘proteasomes’ are
abundant within the cell. Proteasomes are dependent on
ATP and have a ‘barrel’-like structure of inwardly
facing proteases. At either end of this structure
there are large protein complexes that selectively
regulate which proteins enter the proteasome. These
large complexes recognise specific substrates (mainly
misfolded or incompletely folded proteins), bind to
them, then feed them into the proteasome. Degradation
of the protein then ensues – proteolysis performed by
the inwardly facing proteases.
June 17th, 2004 at 8:29 pm
Protein degradation remains an important aspect of the
protein folding system. It is the final chance for a
cell ‘to suppress potentially toxic effects of
expression of aberrant proteins’(Ashkenas J, Byers PH
1997). This not only includes degradation of misfolded
proteins but also degradation of proteins that fail to
assemble completely - this allows the recycling of
amino acids and small peptides.
Large multi-protein complexes that are resident in the
cytoplasm have been shown to degrade misfolded
proteins. These complexes known as ‘proteasomes’ are
abundant within the cell. Proteasomes are dependent on
ATP and have a ‘barrel’-like structure of inwardly
facing proteases. At either end of this structure
there are large protein complexes that selectively
regulate which proteins enter the proteasome. These
large complexes recognise specific substrates (mainly
misfolded or incompletely folded proteins), bind to
them, then feed them into the proteasome. Degradation
of the protein then ensues – proteolysis performed by
the inwardly facing proteases.
June 18th, 2004 at 2:28 am
they stayed around 130ish even pp. a bit higher than i had been but i also
forgot my glucophage the night before so i woke to a 132 rather than a lower
number.
jodi
How were your bg levels? Could your pen have gotten too cold? Pat in ID
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June 18th, 2004 at 6:46 am
it was just the one day thankfully
and i fought that hunger and won over
it. no way was i going to ruin what i have done so far!
jodi
For me, the side effect of slowing of emptying of the stomach
unfortunately ended in mid-April. Over a short time, my appetite
went back to "normal", i.e. too much. I have no explanation, but
since the primary effect of spit, lowering of blood glucose,
continues, I’m still shooting up. I’ve started hoodia to try to curb
the appetite, but now over 2 days, I’ve not seen an effect, good or
bad; I’ll keep it up for a few weeks.
Gary
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June 18th, 2004 at 3:22 pm
now i know with the lantus, if i hit a vein i would drop to a dangerous low
really quickly. then from having to correct either by glucose tabs or foods,
it screws things up. there’s the whole question of did i stay higher due to
the correction or was it that the lantus was spent quicker. that’s why i
wondered about the spit.
as for the bowels, i thought the salad was like a fiber thing. and fiber is
supposed to keep you regular
jodi
IF you hit a vein, I think the only effect would be that the spit went
to work more quickly, not that it would be eliminated more quickly.
A quick check of rxlist.com
================
Metabolism and Elimination
Nonclinical studies have shown that exenatide is predominantly
eliminated by glomerular filtration with subsequent proteolytic
degradation. The mean apparent clearance of exenatide in humans is 9.1
L/h and the mean terminal half-life is 2.4 h. These pharmacokinetic
characteristics of exenatide are independent of the dose. In most
individuals, exenatide concentrations are measurable for approximately
10 h post-dose.
==================
I have a degree in chemistry, but the jargon in the first sentence is
over my head. However, I think it means that byetta is removed by the
kidneys. My guess was confirmed by this bit from byetta.com
========
How is BYETTA metabolized and eliminated?
BYETTA is primarily cleared by the kidneys.
========
All in all, I don’t think you need to worry about hitting a vein.
For your other question, if your diet changed, a chagne in elimination
pattern is to be expected.
Andrew
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